The PRIDE Proteomics database
Cynthia’s hard work has resulted in her proteome data being published online via the ProteomeXchange database PRIDE.
The PRIDE PRoteomics IDEntifications (PRIDE) database is a centralized, standards compliant, public data repository for proteomics data.
Cynthia Martin’s manuscript “Uterine flushing proteome of the tammar wallaby after reactivation from diapause.” was just accepted by the international journal Reproduction. The pre-press manuscript is available at http://www.reproduction-online.org/content/early/2016/08/01/REP-16-0154. The work is a collaboration between Cynthia, Chin Seng Ang, a proteomics specialist at Bio21, and her supervisors Geoff, David and Marilyn. This is the first study to investigate changes in uterine secretion profiles using extremely sensitive, cutting-edge LC-MS/MS approaches, and highlights some of the factors that may be involved in the regulation of embryonic diapause.
Pubmed Record: http://www.ncbi.nlm.nih.gov/pubmed/27486272
Welcome to Teruhito Ishihara, who joins us from Japan for a year to undertake an Honours research project investigating genomic imprinting with a focus on measuring changes in 5-Methyl-cytosine.
Welcome also to Caitlin Cusack, who will be investigating expression of the Insulin receptors during development for a 3rd year Research Project.
Recently published is the result of a collaboration between our laboratory, our past PhD student Cyrma Hearn and Melanie Laird at the University of Sydney, These findings demonstrate that diapause, like pregnancy, is under unilateral endocrine control in the tammar, and that preparation for and maintenance of diapause requires substantial changes to uterine endometrial cell ultrastructure and activity.
Marilyn Renfree among a group of concerned scientists convened a multidisciplinary meeting under the name “Conservation by Cellular Technologies.” The outcome of this meeting was a proposed road map that, if successfully implemented, would ultimately lead to a self-sustaining population of an extremely endangered species are outlined here. This new paper provides an overview of these ideas.
Photomicrographs looking a bit muddy? I have made some notes on a simple way to improve things.
You can download the notes as a PDF file here: Adjusting_Photomicrographs_for_better_appearance
Hot off the press: http://dx.doi.org/10.1016/j.mce.2016.03.030
When 60-day-old tammar wallaby pouch young (Macropus eugenii) are fostered to mothers at 120 days of lactation, their growth, developmental rate and maturation of their GH/IGF axes are markedly accelerated. To determine the effect of fostering on energy intake, body composition and fat accretion, we first measured total body fat and lean mass in these young. Next, we mimicked the triglyceride oleic and palmitic acid composition of 120-day milk by supplementing 60 day young with these fatty acids and comparing their growth with that of growth accelerated young. There was no difference in the weight or growth axis maturation of supplemented young but there was significantly more body fat in these and in the growth-accelerated fostered young than in controls. We conclude that the accelerated growth and GH/IGF axis maturation observed previously in fostered young is most likely due to increased milk consumption and earlier access to specific nutrients.
The cover image, by Marilyn B. Renfree et al., is based on the Advanced Review The Mammalian Blastocyst, DOI: 10.1002/wdev.220. Marilyn B. Renfree et al. would also like to credit and thank fellow colleague, Geoff Shaw, for his design contribution
Another publication has been distinguished by use of our cover page design.
Frankenberg SR, de Barros FRO, Rossant J and Renfree MB (2016) The mammalian blastocyst. Wiley Interdisciplinary Reviews: Developmental Biology.
The full paper is available online at http://onlinelibrary.wiley.com/doi/10.1002/wdev.220/abstract
Every now and again I find documents where the revisions balloons are unreadable because the font is wrong. This can be fixed. Press Ctrl-Alt-Shift-S to open the Style window Continue reading
A lot of people use fonts like times new roman in their presentations. Times and similar fonts are great for blocks of text on a book page, but there are issues in presentations where you have small amounts of text and want maximum legibility. The Serif fonts tend to get hard to see at small sizes reducing legibility. Here is an example to show how Arial, for example, is easier to read than Times New Roman, especially at smaller font sizes (or large font sizes viewed from the back of a large lecture theatre).
Arial vs Times New Roman